We recently described that Transferrin Receptor 2 (TfR2) is expressed in erythroblasts. We show that TfR2 associates with the receptor of erythropoietin (Epo) the main regulator of erythropoïesis. TfR2 is an escort protein for the EpoR cell surface expression and is regulating differentiation, showing thus a new function for TfR2. The role of TfR2 was indeed only described in hepatocytes where TfR2 is implicated in iron metabolism via hepcidin expression regulation. Furthermore we demonstrated that Tfr2 and Epo are crucial for the secretion of GDF-15 by erythroblasts. GDF-15 was identified as a hepcidin-suppression factor highly expressed by erythroblasts from patients with ineffective erythropoiesis, like b-thalassemic patients. GDF- 15 is also overexpressed in tumors but its role in non pathological condition is not known.
-The Postdoctoral scientist will identify the external inducers for GDF-15 secretion and the transcription factors involved in GDF-15 production in erythroblasts. -He/she will also determine the role of GDF-15 in erythropoiesis and iron metabolism connexion. -The candidate will benefit from all the technical platforms facilities at the Institute Cochin.