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Postdoctoral Position in Macromolecular Crystallography at Helmholtz Centre for Infection Research, Germany

The Young Investigators Group “Structural Biology of Autophagy” studies molecular protein complexes involved in the regulation of autophagy in the context of infectious diseases and pathogen defense. Project: The aim of the project is the structural and biochemical characterization of key regulatory proteins/protein complexes in autophagy, a process involved in the degradation of and defense against a large variety of pathogens. A detailed structural insight into these regulatory autophagy pathways will help in understanding the molecular basis of autophagy-related diseases with the goal of providing new strategies for therapeutic approaches against infectious diseases. Methods will include molecular biology, protein expression and purification, X-ray crystallography and biophysical methods (ITC, fluorescence, Biacore).

-Candidates should hold a PhD in life sciences at the time of their employment. -Solid knowledge in crystallography (demonstrated by an excellent publication record), ability to work as part of an international team and good communication skills in English (written and spoken) are a prerequisite. -Experience in protein expression (E. coli, Baculovirus/Insect cell) and purification will be considered an advantage.