Our research team focuses on genetic and functional studies to identify and evaluate novel genes that are implicated in T-cell acute lymphoblastic leukemia (T-ALL). We have recently identified PHF6 as a novel tumor suppressor gene in T-ALL (Nature Genetics, 2010) and are currently evaluating its functional role. We also wish to evaluate the functional role of other, non-coding genes (miRNAs, lncRNAs) that might be implicated in T-ALL development. We therefore aim to develop a novel zebrafish model to study these T-ALL genes. In recent years, zebrafish have emerged as a potent model organism to study hematological diseases and can be easily modified genetically and used in large screens with compounds that might be of benefit in leukemia treatment.
-Knowledge/Experience Background: master in biomedical sciences/biotechnology/biochemistry/pharmaceutical sciences/medicine (MD); bio-engineer (cell and gene technology) or equivalent; high grades are certainly recommended; experience with in vivo models is a plus but not required – Skills Eager to learn and to work independently; strong communicative skills and a team-player (as the project will be interdisciplinary) -Attitudes Strongly motivated to perform scientific research; problem solving and critical attitude; personal interest in model organisms. Hoe solliciteren