Our group is investigating the role of T cell immunology in viral hepatitis such as Hepatitis C (HCV) and in hepatocellular carcinoma (HCC), respec-tively. Several studies have shown the important role of T cells in elimination and immunopathogenesis of HCV infection. In HCC, Alpha-Fetoprotein (AFP) is overexpressed in 50% of the patients. In the mouse model, the in-duction of T cell responses were associated with significant protective anti-tumoral T cell responses. The aim of this project is to achieve new aspects in HCV-specific CD4+ T cell responses in chronic and eliminated HCV infection as well as HCC-specific CD4+ T cell responses in HCC.
Anforderungen: For our young team we are looking for a PhD-student with high scientific interest and motivation. We offer an intensive supervision with the unique chance to achieve a broad spectrum of modern immunological tech-niques. Knowledge in FACS technique would be desirable, but not manda-tory. All required methods are readily established in our lab. We look forward to hearing from you.